HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-chloropyrimidine → (1-(5-Bromopyrimidin-2-yl)-3-(hydroxymethyl)-1H-indol-6-yl)(morpholino)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| Reactant | (1-(5-Bromopyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone | HCID 118666053 | — |
| Reactant | (3-(Hydroxymethyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118666232 | — |
| Product | (1-(5-Bromopyrimidin-2-yl)-3-(hydroxymethyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118666263 | — |
Reaction Steps
Prepared from 27b) (700 mg, 2.69 mmol, 1.0 eq) and 5-bromo-2-chloropyrimidine (520 mg, 2.69 mmol, 1.0 eq) in an analogous manner to the procedure of 1c). The raw product was purified by column chromatography [100-200 mesh; ethyl acetate/petrolether=7:3]. White solid. Yield: 400 mg (35% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-c85194d36f0f48fa954d55ccfe24f875 |
| Source note | uspto-grants-2016_04 |