HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorophenylboronic acid → (1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(hydroxymethyl)-1H-indol-6-yl)(morpholino)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorophenylboronic acid | HCID 2734354 | — |
| Reactant | (1-(5-Bromopyrimidin-2-yl)-3-(hydroxymethyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118666263 | — |
| Product | (1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(hydroxymethyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118666239 | — |
Reaction Steps
Prepared from 27c) (400 mg, 0.959 mmol, 1.0 eq) and (2-fluorophenyl)boronic acid (133 mg, 0.959 mmol, 1.0 eq) according to general procedure 1. White solid. Yield: 230 mg (55% of theory). Melting range: 190-194° C. HPLC (method 1): Rt=9.69 min. Mass spectroscopy: m/z: [M+H]+=433.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-507d3725e5ad447c99d41e29aa2fb2f1 |
| Source note | uspto-grants-2016_04 |