HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → (1-(5-(1-Methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | (1-(5-(4-Methoxypyridin-2-yl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118671977 | — |
| Reactant | (1-(5-(1-Methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone | HCID 118676819 | — |
| Product | (1-(5-(1-Methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118666181 | — |
Reaction Steps
The compound obtained in 148a) (380 mg, 0.921 mmol, 1.0 eq) was oxidized with m-chloroperoxybenzoic acid in analogy to the instructions from 141c). White solid. Yield: 150 mg (36% of theory). Melting range: 208-212° C. HPLC (method 6): Rt=7.51 min. Mass spectroscopy: m/z: [M+H]+=451.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-bcb06ff360e941839af8eff173ab9db5 |
| Source note | uspto-grants-2016_04 |