HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Methylamino)propan-2-ol → 1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-N-(2-hydroxypropyl)-N-methyl-3-(methylsulfinyl)-1H-indole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Methylamino)propan-2-ol | HCID 86049 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indole-6-carboxylic acid | HCID 118666089 | — |
| Product | 1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-N-(2-hydroxypropyl)-N-methyl-3-(methylsulfinyl)-1H-indole-6-carboxamide | HCID 118671947 | — |
Reaction Steps
HATU coupling of 1-(5-(2-fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indole-6-carboxylic acid with 1-(methylamino)propan-2-ol. White solid. Yield: 0.16 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-1e75ef4f78bc4c54b92506f6baa29c23 |
| Source note | uspto-grants-2016_04 |