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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 630491Generated: October 26, 2026

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 118671951, compound

https://huagongshe.com/reaction/630491

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 9886157—
Reactant(S)-3-MethoxypyrrolidineHCID 26191850—
Reactant1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indole-6-carboxylic acidHCID 118666089—
ProductHCID 118671951HCID 118671951—

Reaction Steps

Amide coupling of 1-(5-(2-fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indole-6-carboxylic acid with (S)-3-methoxypyrrolidine utilizing HATU as coupling reagent. White solid. Yield: 100 mg (85% of theory)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09315490B2
Source datasetuspto-grants-2016_04
ORD IDord-f67e6c8e441d46c5aee6a62c1749d755
Source noteuspto-grants-2016_04