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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 630492Generated: November 1, 2026

Propylphosphonic anhydride → HCID 118671962, compound

https://huagongshe.com/reaction/630492

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPropylphosphonic anhydrideHCID 111923—
Reactant(1S,4S)-tert-butyl 2,5-diazabicyclo(2.2.1)heptane-2-carboxylateHCID 2760898—
Reactant1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indole-6-carboxylic acidHCID 118666089—
ProductHCID 118671962HCID 118671962—

Reaction Steps

Prepared from 1-(5-(2-fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indole-6-carboxylic acid and tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate in two steps comprising a T3P coupling and a TFA-catalyzed removal of the Boc protecting group. Light yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09315490B2
Source datasetuspto-grants-2016_04
ORD IDord-627fd217e7fd4098a145e408955cfc91
Source noteuspto-grants-2016_04