Lithium hydroxide, monohydrate → HCID 118676846, compound

Participants

Reaction Steps

Lithium hydroxide monohydrate (0.837 g, 19.94 mmol, 3 eq) was added to a solution of 244a) (2.5 g, 6.64 mmol, 1 eq) in water/THF (1:1, 40 mL) and the reaction mixture was stirred for 16 h at room temperature. The solvents were removed under reduced pressure and the residue was dissolved in water (100 mL), washed with ether (50 mL) and acidified with 2N hydrogen chloride solution. The aqueous phase was then extracted with ethyl acetate (2×100 mL) and the combined organic layers were washed with water and brine (50 mL), dried over sodium sulfate, and evaporated. White solid. Yield: 1.5 g (63% of theory)

Provenance & Evidence