HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-chloropyridine → (1-(5-(4-Chloropyridin-2-yl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-chloropyridine | HCID 2762836 | — |
| Reactant | (1-(5-Bromopyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118666026 | — |
| Reactant | (1-(5-(4-(2-Hydroxypropan-2-yl)pyridin-2-yl)pyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino)methanone | HCID 118666145 | — |
| Product | (1-(5-(4-Chloropyridin-2-yl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)methanone | HCID 118666088 | — |
Reaction Steps
Prepared from (1-(5-bromopyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)(morpholino)-methanone (0.5 g, 1.11 mmol) and 2-bromo-4-chloropyridine (0.23 g, 1.22 mmol) analogously to the experimental procedure for 289a). White solid. Yield: 61 mg (11% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-88aa0a80d8324aa69676cab35d892fd5 |
| Source note | uspto-grants-2016_04 |