HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Bromo-4-fluorophenyl)ethanol → Methyl 1-(5-(2-fluoro-5-(1-hydroxyethyl)phenyl)pyrimidin-2-yl)-3-(methylthio)-1H-indole-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Bromo-4-fluorophenyl)ethanol | HCID 20785306 | — |
| Reactant | Methyl 1-(5-bromopyrimidin-2-yl)-3-(methylthio)-1H-indole-6-carboxylate | HCID 118666039 | — |
| Product | Methyl 1-(5-(2-fluoro-5-(1-hydroxyethyl)phenyl)pyrimidin-2-yl)-3-(methylthio)-1H-indole-6-carboxylate | HCID 118666176 | — |
Reaction Steps
Synthesized from methyl 1-(5-bromopyrimidin-2-yl)-3-(methylthio)-1H-indole-6-carboxylate (1.0 g, 2.65 mmol) and 1-(3-bromo-4-fluorophenyl)ethanol (0.87 g, 3.98 mmol) analogously to the experimental procedure 289a). Yellow solid. Yield: 1.0 g (89% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-95fa63f4d9e9445eb438fec3bcca8033 |
| Source note | uspto-grants-2016_04 |