2-Fluoro-5-methylbenzeneboronic acid → Methyl 2-(1-(5-(2-fluoro-5-methylphenyl)pyrimidin-2-yl)-N-methyl-3-(methylthio)-1H-indole-6-carboxamido)acetate

Participants

Reaction Steps

Suzuki coupling of 304a) (0.5 g, 1.11 mmol) and (2-fluoro-5-methylphenyl)boronic acid (0.34 g, 2.22 mmol) under use of (Ataphos)2PdCl2 (79 mg, 0.11 mmol) as catalyst analogously to the protocol for example 261. White solid. Yield: 0.51 g (96% of theory)

Provenance & Evidence