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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 630534Generated: October 31, 2026

Lithium hydroxide, monohydrate → 2-(1-(5-(2-Fluoro-5-methylphenyl)pyrimidin-2-yl)-N-methyl-3-(methylthio)-1H-indole-6-carboxamido)acetic acid

https://huagongshe.com/reaction/630534

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium hydroxide, monohydrateHCID 168937—
ReactantMethyl 2-(1-(5-(2-fluoro-5-methylphenyl)pyrimidin-2-yl)-N-methyl-3-(methylthio)-1H-indole-6-carboxamido)acetateHCID 118666155—
SolventOxolane--water (1/1)HCID 21881883—
Product2-(1-(5-(2-Fluoro-5-methylphenyl)pyrimidin-2-yl)-N-methyl-3-(methylthio)-1H-indole-6-carboxamido)acetic acidHCID 118666271—

Reaction Steps

Ester hydrolysis of 304b) (0.5 g, 1.05 mmol) with lithium hydroxide monohydrate in THF/water. White solid. Yield: 0.48 g (98% of theory)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09315490B2
Source datasetuspto-grants-2016_04
ORD IDord-2fc36a1b4ead42e68248790e2c6fe16a
Source noteuspto-grants-2016_04