HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 1-(5-(2-Fluoro-5-methylphenyl)pyrimidin-2-yl)-N-methyl-N-(2-(methylamino)-2-oxoethyl)-3-(methylsulfinyl)-1H-indole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 1-(5-(2-Fluoro-5-methylphenyl)pyrimidin-2-yl)-N-methyl-N-(2-(methylamino)-2-oxoethyl)-3-(methylthio)-1H-indole-6-carboxamide | HCID 118676785 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(5-(2-Fluoro-5-methylphenyl)pyrimidin-2-yl)-N-methyl-N-(2-(methylamino)-2-oxoethyl)-3-(methylsulfinyl)-1H-indole-6-carboxamide | HCID 118666141 | — |
Reaction Steps
Oxidation of 304d) (0.1 g, 0.209 mmol) with m-chloroperoxybenzoic acid (77%, 0.038 g, 0.167 mmol) in dichloromethane (10 mL). White solid. Yield: 0.065 g (63% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-e2af40944b954cedb9a8bdb52e83b83e |
| Source note | uspto-grants-2016_04 |