反应详情

Dess-Martin periodinane (0.541 g, 1.27 mmol) was added at 0° C. to a solution of 331b) (0.345 g, 0.85 mmol) in dichloromethane (25 mL). The resulting mixture was stirred at this temperature for 3 h and then filtered through celite. The filter was rinsed with dichloromethane (2×30 mL) and the filtrate was washed with saturated sodium hydrogen carbonate solution (3×20 mL) and brine (20 mL), dried over sodium sulfate and concentrated. Light yellow solid. Yield: 0.32 g (93% of theory)

1. filtrationfiltered through celite
2. washThe filter was rinsed with dichloromethane (2×30 mL)
3. washthe filtrate was washed with saturated sodium hydrogen carbonate solution (3×20 mL) and brine (20 mL)
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated