HRID630616

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12298

Pentanamide

C5H11NO

HCID86715363

未命名化合物

结构：C#CCNC(=O)c1cccc(S(=O)(=O)OC[C@@](C)(O)C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCc2ccccc2)NC(=O)CN2CCOCC2)c1

HCID86715390

未命名化合物

PRODUCTS

生成物

结构：C#CCOc1cc(OC)c(S(=O)(=O)OCC(C)(O)C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCc2ccccc2)NC(=O)CN2CCOCC2)c(OC)c1

HCID86715362

未命名化合物

PROCEDURE

实验过程

Prepared in a similar manner to compound 13, except from 4-(propargyloxy)-2,6-dimethoxybenzene-1-sulfonyl chloride and (S)—N—((S)-1-(((2R,4S)-1,2-dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-242-morpholinoacetamido)-4-phenylbutanamido)pentanamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9164530a946e4cc7aaa6da20ad36154d
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09315542B2
来源说明: uspto-grants-2016_04

反应 SMILES

C(NC(C1C=C(S([O:16][CH2:17][C@:18]([OH:68])([CH3:67])[C:19](=[O:66])[C@H:20]([CH2:62][CH:63]([CH3:65])[CH3:64])[NH:21][C:22](=[O:61])[C@H:23]([CH2:54][C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=2)[NH:24][C:25](=[O:53])[C@H:26]([CH2:49][CH:50]([CH3:52])[CH3:51])[NH:27][C:28](=[O:48])[C@H:29]([CH2:40][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[NH:30][C:31](=[O:39])[CH2:32][N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)(=O)=O)C=CC=1)=O)C#C.[CH2:69]([O:72][C:73]1[CH:78]=[C:77]([O:79][CH3:80])[C:76]([S:81](Cl)(=[O:83])=[O:82])=[C:75]([O:85][CH3:86])[CH:74]=1)[C:70]#[CH:71].C(N)(=O)CCCC>>[CH3:80][O:79][C:77]1[CH:78]=[C:73]([O:72][CH2:69][C:70]#[CH:71])[CH:74]=[C:75]([O:85][CH3:86])[C:76]=1[S:81]([O:16][CH2:17][C:18]([OH:68])([CH3:67])[C:19](=[O:66])[C@H:20]([CH2:62][CH:63]([CH3:64])[CH3:65])[NH:21][C:22](=[O:61])[C@H:23]([CH2:54][C:55]1[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=1)[NH:24][C:25](=[O:53])[C@H:26]([CH2:49][CH:50]([CH3:52])[CH3:51])[NH:27][C:28](=[O:48])[C@H:29]([CH2:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[NH:30][C:31](=[O:39])[CH2:32][N:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1)(=[O:83])=[O:82]