3-(Trifluoromethoxy)benzylamine → HCID 86728207, compound

HRID 63063Notes

Reaction equation

HRID 63063 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8].F[C:15]1[CH:23]=[N:22][CH:21]=[CH:20][C:16]=1[C:17]([OH:19])=[O:18]>>[F:1][C:2]([F:12])([F:13])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH:8][C:20]1[CH:21]=[N:22][CH:23]=[CH:15][C:16]=1[C:17]([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 1452643-(Trifluoromethoxy)benzylamineHCID 3453613-Fluoropyridine-4-carboxylic acid

Product 1

HCID 86728207HCID 86728207, compoundYield 4%

Procedure

The title compound was prepared in 4% yield from 3-trifluoromethoxy-benzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.47 (br s, 1H), 8.11 (br s, 1H), 7.84 (br s, 1H), 7.59 (s, 1H), 7.24-7.51 (m, 4H), 4.64 (s, 2H). [M+H] calc'd for C14H11F3N2O3, 313. found 313.

Sources & evidence

ORD record
ord-b6517938a332462bb0886ac9efac015b
Source dataset
uspto-grants-2016_09
Patent number
US09447045B2

Reaction notes

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