Water → HCID 86687095, compound

Participants

Reaction Steps

To a solution of Intermediate 77a (233 mg, 0.931 mmol) and Et3N (0.195 mL, 1.40 mmol) in dry DCM (5 mL) at RT under N2, was added triisopropylsilyl trifluoromethanesulfonate (0.313 mL, 1.16 mmol) and the yellow solution stirred at RT for 30 min. Water (5 mL) was added and the mixture shaken. The aqueous was extracted with DCM (5 mL), then the combined organics passed through a hydrophobic fit and concentrated in vacuo to leave a yellow oil. FCC, using 1-5% MeOH in DCM, gave the title compound as a yellow oil (333 mg, 88%). LCMS (Method 3): Rt 5.23 min, m/z 407 [MH+].

Provenance & Evidence