反应详情

温度

40 °C

To a solution of 6-methoxy-1-tetralone (200 mg, 1.1 mmol) in ACN (20 mL) was added Selectfluor (603 mg, 1.7 mmol) at rt, and the reaction was stirred at 40° C. overnight. The reaction was filtered and concentrated. The residue was dissolved in EtOAc (40 mL), filtered, and concentrated. Purification by silica gel chromatography (PE/EtOAc/DCM=20:1:2) gave 90 mg (41%) of the title compound as a yellow solid. [M+H] Calc'd for C11H11FO2, 195. Found, 195.

1. filtrationThe reaction was filtered
2. concentrationconcentrated
3. dissolutionThe residue was dissolved in EtOAc (40 mL)
4. filtrationfiltered
5. concentrationconcentrated
6. customPurification by silica gel chromatography (PE/EtOAc/DCM=20:1:2)