Water → HCID 131735416, compound

Participants

Reaction Steps

In order to form a functional group which may be conjugated to PLL in paclitaxel (PTX), PTX, succinic anhydride (SA) and 4-dimethylaminopyridine (DMAP) were put into a pyridine solution, and then were reacted for 3 hours. After 3 hours, the reaction solution was mixed with dichloromethane such that a volume ratio therebetween was 1:1, the reaction solution was put into a separatory funnel with water, and thereby a remaining material after the reaction was removed. A solution obtained from the separatory funnel was deposited in a hexane to obtain PTX-SA.

Provenance & Evidence