反应详情

The titled compound was synthesized according to the procedure described for preparation of N4-cyclopentyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine (Example 29) using [4-(trifluoromethyl)phenyl]amine instead of cyclopentanamine. The crude material was purified by column chromatography eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1), and then the final product was washed with diethyl ether to afford the titled compound as a light-yellow solid. 1H NMR (300 MHz, CDCl3) δ ppm 2.10 (s, 3H), 2.37 (s, 3H), 4.72 (d, J=5.4 Hz, 2H), 6.07 (bs, 1H), 6.55 (bs, 1H), 7.18 (t, J=7.0 Hz, 1H), 7.34 (d, J=7.5 Hz, 1H), 7.48 (d, J=8.6 Hz, 2H), 7.58-7.65 (m 3H), 8.58 (d, J=3.2 Hz, 1H); MS (ESI) m/z 374.7 (M+1)+.

1. customThe titled compound was synthesized
2. customThe crude material was purified by column chromatography
3. washeluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1)
4. washthe final product was washed with diethyl ether