HRID6316

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1140

Toluene

C7H8

HCID13907537

未命名化合物

HCID13997679

未命名化合物

PRODUCTS

生成物

结构：C=CCCCCCCOc1ccc(C(=O)OC2(C(=O)OCC(C)CC)C=CC(c3ccccc3)=CC2)cc1

HCID67568782

未命名化合物

收率 45%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A toluene solution containing 10 g of 2-methylbutyl 4'-hydroxybiphenyl-4-carboxylate and 3 g of pyridine was added dropwise to the above-described toluene solution of the acid chloride compound. After conclusion of dropping, the temperature was raised, and reaction was carried out for 8 hours at 50° C. After conclusion of the reaction, the product was washed with water and dried over magnesium sulfate, and the dried product was concentrated under reduced pressure. The residue was recrystallized from ethanol to obtain 8.2 g of the objective ester compound. (Yield: 45%)

WORKUP

后处理

temperaturethe temperature was raised
customreaction
customAfter conclusion of the reaction
washthe product was washed with water
dry with materialdried over magnesium sulfate
concentrationthe dried product was concentrated under reduced pressure
customThe residue was recrystallized from ethanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-16d4578764164207b3fbaf490dfbb2e2
来源数据集: uspto-grants-1993_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05248446
来源说明: uspto-grants-1993_09

反应 SMILES

C1(C)C=CC=CC=1.O[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([O:23][CH2:24][CH:25]([CH3:28])[CH2:26][CH3:27])=[O:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.[CH2:29]([O:37][C:38]1[CH:46]=[CH:45][C:41]([C:42]([OH:44])=[O:43])=[CH:40][CH:39]=1)[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH:35]=[CH2:36]>N1C=CC=CC=1>[CH2:29]([O:37][C:38]1[CH:39]=[CH:40][C:41]([C:42]([O:44][C:18]2([C:21]([O:23][CH2:24][CH:25]([CH3:28])[CH2:26][CH3:27])=[O:22])[CH:19]=[CH:20][C:15]([C:12]3[CH:13]=[CH:14][CH:9]=[CH:10][CH:11]=3)=[CH:16][CH2:17]2)=[O:43])=[CH:45][CH:46]=1)[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH:35]=[CH2:36]