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HRID631657

反应详情

EQUATION

反应方程式

HRID 631657 的结构方程式

REACTANTS

反应物

2
结构：NC(=O)Oc1ccccc1
HCID69322

Phenyl carbamate

C7H7NO2

结构：COc1ccc(-n2nc(C(C)(F)F)cc2N)cc1
HCID66875898

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(-n2nc(C(C)(F)F)cc2NC(=O)Oc2ccccc2)cc1
HCID67159635

未命名化合物

收率 64%

PROCEDURE

实验过程

3-(1,1-difluoroethyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-amine was converted to the phenyl carbamate using the procedure for Example 282A Step 2. Purification using silica gel chromatography eluting with EtOAc/hexane (5-40%) afforded phenyl 3-(1,1-difluoroethyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-ylcarbamate in 64% yield. LC-MS (ESI) m/z 374 (M−H)−

WORKUP

后处理

  1. customPurification
  2. washeluting with EtOAc/hexane (5-40%)