HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pentanenitrile, 4,4-dimethyl-3-oxo- → 3-(Tert-butyl)-1-(3-pyridyl)pyrazole-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| Reactant | 3-Hydrazinopyridine | HCID 10909519 | — |
| Product | 3-(Tert-butyl)-1-(3-pyridyl)pyrazole-5-amine | HCID 46196775 | 77.3% |
Reaction Steps
Following the procedure in Example 161A Step 3, 3-hydrazinylpyridine (501 mg, 4.0 mmol) and 4,4-dimethyl-3-oxopentanenitrile (437 mg, 4.0 mmol) were reacted to give 3-tert-butyl-1-(pyridin-3-yl)-1H-pyrazol-5-amine (667 mg, 3.09 mmol, 77%), LC-MS (ESI) m/z 217 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09320739B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-529e66e89a164ed6a369230e2e7b8c01 |
| Source note | uspto-grants-2016_04 |