Phenyl chloroformate → phenyl 3-tert-butyl-1-isobutyl-1H-pyrazol-5-ylcarbamate

HRID 631687Notes

Reaction equation

Cl.[C:2]([C:6]1[CH:10]=[C:9]([NH2:11])[N:8]([CH2:12][CH:13]([CH3:15])[CH3:14])[N:7]=1)([CH3:5])([CH3:4])[CH3:3].Cl[C:17]([O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:18]>>[C:2]([C:6]1[CH:10]=[C:9]([NH:11][C:17](=[O:18])[O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:8]([CH2:12][CH:13]([CH3:15])[CH3:14])[N:7]=1)([CH3:5])([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 15891Phenyl chloroformate

HCID 668762943-tert-butyl-1-isobutyl-1H-pyrazol-5-amine hydrochloride

Product 1

HCID 66876741phenyl 3-tert-butyl-1-isobutyl-1H-pyrazol-5-ylcarbamate

Procedure

Following the procedure described for Example 330A Step 2, reaction of 3-tert-butyl-1-isobutyl-1H-pyrazol-5-amine hydrochloride with phenyl chloroformate, afforded phenyl 3-tert-butyl-1-isobutyl-1H-pyrazol-5-ylcarbamate which was used in the subsequent step.

Sources & evidence

ORD record: ord-cfafa94659e7479ead69e086d7e55832
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09320739B2

Reaction notes

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