反应详情

13.7 g of p-hydroxybenzoic acid and 11.4 g of (S)-(+)-3-methyl-1-pentanol were refluxed for 10 hours in toluene in the presence of sulfuric acid, while removing out the generated water from the reaction system. Subsequently, the reaction solution was washed with water to remove the sulfuric acid out. The reaction solution was then dried, concentrated, and purified by column chromatography, to obtain 17.8 g of the objective ester compound (liquid state at room temperature ([α]D23 =+7.8° (CHCl3)). (Yield: 80%)

1. customwhile removing out the generated water from the reaction system
2. washSubsequently, the reaction solution was washed with water
3. customto remove the sulfuric acid out
4. customThe reaction solution was then dried
5. concentrationconcentrated
6. custompurified by column chromatography