HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Phenylmethyl)hydrazine → 1-BENZYL-3-TERT-BUTYL-1H-PYRAZOL-5-AMINE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Phenylmethyl)hydrazine | HCID 11157 | — |
| Reactant | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| Product | 1-BENZYL-3-TERT-BUTYL-1H-PYRAZOL-5-AMINE | HCID 16769290 | 36.3% |
Reaction Steps
Following the procedure in Example 161A Step 3, benzylhydrazine (977 mg, 8.0 mmol) and 4,4-dimethyl-3-oxopentanenitrile (1.0 g, 8.0 mmol) to give 1-benzyl-3-tert-butyl-1H-pyrazol-5-amine (666 mg, 2.90 mmol, 36%). 1H NMR (300 MHz, DMSO-d6) δ 7.32-7.21 (m, 3H), 7.09 (d, 2H), 5.17 (s, 1H), 5.05 (d, 4H), 1.15 (s, 9H); LC-MS (ESI) m/z 230 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09320739B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-42d69be8b88b4657ab346a4713db11cc |
| Source note | uspto-grants-2016_04 |