Hydrochloric Acid → N1-(4-Methyl-1,3-thiazol-2-yl)ethane-1,2-diamine hydrochloride

Participants

Reaction Steps

To a solution of tert-butyl N-[2-[(4-methylthiazol-2-yl)amino]ethyl]carbamate (435 mg, 1.69 mmol) in acetone (20 mL) was added HCl (4N in dioxane, 2.6 mL, 10.40 mmol) and the reaction mixture was stirred at room temperature overnight. The resulting precipitate was isolated by filtration, washed with acetone and diethylether and allowed to dry at ambient conditions to yield 290 mg of an off-white solid (1.497 mmol, 89%). MS(ESI) m/z=158.1 [M+1]+.

Provenance & Evidence