2-Bromo-6-methylpyrazine → N-(6-Methylpyrazin-2-yl)ethane-1,2-diamine
Reaction equation
Br[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([CH3:8])[N:3]=1>C(N)CN>[CH3:8][C:4]1[N:3]=[C:2]([NH:3][CH2:2][CH2:7][NH2:6])[CH:7]=[N:6][CH:5]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 150 °C
Procedure
2-Bromo-6-methyl-pyrazine (220 mg, 1.44 mmol) was dissolved in ethylenediamine (2 ml) and stirred under microwave heating for 30 minutes at 150° C. in a closed vial. The reaction mixture was concentrated under reduced pressure, toluene was added and the volatiles were removed under reduced pressure. The last step was repeated two times. The remaining solid was used directly in the next step.
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure, toluene
- additionwas added
- customthe volatiles were removed under reduced pressure
Sources & evidence
- ORD record
- ord-8724731315e14d7e9716c8b00c40b568
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321724B2
Reaction notes
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