Oxalyl chloride → (E)-4,4,4-Trifluoro-1-[7-(4-methyl-2-pyridyl)-2,7-diazaspiro[4.5]decan-2-yl]but-2-en-1-one

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Reaction Steps

(E)-4,4,4-Trifluorobut-2-enoic acid (32 mg, 0.23 mmol) was dissolved in dichloromethane (0.5 ml containing one drop of dimethyl formamide), oxalyl chloride was added (20 μl, 0.23 mmol) and the solution was stirred at room temperature for 15 minutes. This solution was added to a solution of 7-(4-methyl-2-pyridyl)-2,7-diazaspiro[4.5]decane dihydrochloride (40 mg, 0.13 mmol, half of the residue from step B) and EDIPA (125 μl, 0.8 mmol) in anhydrous dichloromethane (2 ml) and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by preparative HPLC (Waters XBridge, gradient of water containing 0.1% NH3 and 10% to 100% acetonitrile) to yield 10 mg of a solid (0.028 mmol, 9% yield for two steps).

Provenance & Evidence