反应详情

The titled compound was synthesized according to the procedure described for preparation of N4-cyclopentyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine (Example 29) using (4-fluorobenzyl)amine instead of cyclopentanamine. The crude material was purified by column chromatography eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1), and then the final product was washed with diethyl ether to afford the titled compound as a white solid. 1H NMR (300 MHz, CDCl3) δ ppm 1.92 (s, 3H), 2.27 (s, 3H), 4.56 (d, J=3.8 Hz, 2H), 4.72 (d, J=2.8 Hz, 2H), 4.78 (bs, 1H), 5.70 (bs, 1H), 6.94 (t, J=8.6 Hz, 2H), 7.13 (d, J=7.8 Hz, 1H), 7.20 (t, J=7.5 Hz, 2H), 7.29 (bs, 1H), 7.57 (t, J=7.5 Hz, 1H), 8.57 (d, J=3.2 Hz, 1H); MS (ESI) m/z 338.8 (M+1)+.

1. customThe titled compound was synthesized
2. customThe crude material was purified by column chromatography
3. washeluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1)
4. washthe final product was washed with diethyl ether