反应详情

To a solution of 2-amino-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester (Intermediate 5, 1.5 g) in pyridine (20 mL) was added benzenesulfonyl chloride (0.95 mL). The mixture was stirred for 1 hour then concentrated under vacuum. The residue was dissolved in ethyl acetate and washed with 1N hydrochloric acid, dried with magnesium sulfate and filtered. The filtrate was evaporated under vacuum to give the title compound as an off-white crystalline solid (2.4 g).

1. concentrationthen concentrated under vacuum
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed with 1N hydrochloric acid
4. dry with materialdried with magnesium sulfate
5. filtrationfiltered
6. customThe filtrate was evaporated under vacuum