反应详情

A slurry of palladium on carbon (10%; 0.025 g) in DCM (5 mL) was added to a solution of 2-nitro-6-cyclopropylbenzonitrile (Intermediate 11, 0.25 g) in ethanol (15 mL) under nitrogen. The nitrogen atmosphere was exchanged for hydrogen and the mixture was stirred for 48 hours. The mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by flash chromatography on silica, eluting with a mixture of ethyl acetate and cyclohexane. The fractions containing the desired product were combined and evaporated to give the title compound as a colorless oil (0.082 g).

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated under vacuum
3. customThe residue was purified by flash chromatography on silica
4. washeluting with a mixture of ethyl acetate and cyclohexane
5. additionThe fractions containing the desired product
6. customevaporated