p-Toluenesulfonic acid → HCID 2763195, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred mixture of 2 (1.34 mmol) and anhydrous p-toluenesulphonic acid (72 h under vacuum in the presence of P2O5) (1.43 mmol), kept at 0° C. under N2, trifluoroacetic acid (3 mL) was added dropwise in the course of 10 min. The solution was reacted under stirring at 0° C. for 15 min, allowed to reach room temperature, and concentrated at a temperature below 30° C. The oily residue was kept under vacuum for 1 h, and the resulting white solid triturated and washed with dry diethyl ether, then kept under vacuum for 24 h. Yield 81%. Mp and 1H NMR are in accordance with literature (Arnold, et al., 1988).

Provenance & Evidence