反应详情

To a solution of 40e (0.357 g, 1 mmoL) in 40 mL anhydrous CH2Cl2 was added Dess-Martin reagent (0.848 g, 2 mmol). The mixture was allowed to stir for 30 min and quenched with sat. Na2S2O3 solution, extracted with ethyl acetate and dried with MgSO4. The solvent was removed under reduced pressure to yield a crude product, which was purified by column chromatography to give pure compound 1e (80.1%). 1H NMR (CDCl3) δ 8.33 (s, 1H), 8.04 (m, 2H), 7.51 (m, 3H), 7.18 (s, 2H), 3.96 (s, 3H), 3.93 (s, 6H); MS (ESI) m/z 378.1 (M+H)+.

1. customquenched with sat. Na2S2O3 solution
2. extractionextracted with ethyl acetate
3. dry with materialdried with MgSO4
4. customThe solvent was removed under reduced pressure
5. customto yield a crude product, which
6. customwas purified by column chromatography