Triethylamine → [5-(4-bromo-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-carbamic acid 1-(3-trifluoromethyl-phenyl)-ethyl ester

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Reaction Steps

5-(4-Bromophenyl)-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid (from step 4a in Example 1, 517 mg, 1.83 mmol) was suspended in 10 mL of toluene. Triethylamine (0.27 mL) was added followed by DPPA (530 mg, 1.92 mmol) in toluene (2 mL). The mixture was stirred for 10 minutes. 3-Trifluoromethylphenylethanol (383 mg, 2.02 mmol) in toluene (2 mL) was added. The mixture was stirred at 85° C. for 3 hrs. The mixture was extracted with ethyl acetate and water. The organic layer was washed with brine and dried. Solvents were evaporated and the residue was purified by ISCO flash column chromatography (0% to 50% ethyl acetate in hexanes, 40 g silica gel) to give [5-(4-bromo-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-carbamic acid 1-(3-trifluoromethyl-phenyl)-ethyl ester as an amorphous fluffy white powder (700 mg, 81.4% yield). LC/MS calcd for C19H16BrF3N4O2 (m/e) 468.0, obsd 468.9 (M+H); 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.35-1.70 (br, 3H), 3.85 (s, 3H), 5.85 (br, 1H), 7.30-7.90 (m, 8H), 10.01 (br s, 1H).

Provenance & Evidence