反应详情

To a solution of (R)-1-(4′-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-1,2,3-triazol-4-yl)biphenyl-3-yl)cyclopropanecarboxylic acid ethyl ester (90 mg, 0.176 mmol) in THF (5 mL) and ethanol (5 mL) was added an excess of sodium hydroxide (1.76 mL, 1.76 mmol, 1.0 M) in water at room temperature. The resulting colorless solution was stirred for 20 h at which time LCMS analysis indicated the absence of starting material. Then, the solvent was removed under vacuum and the basic aqueous layer was neutralized with 1.0 N HCl. The resulting white solids were collected by filtration and washed with water and hexanes. After air drying, 75 mg (88% yield) of the (R)-1-(4′-(1-methyl-5-((1-phenylethoxy)carbonylamino)-1H-1,2,3-triazol-4-yl)biphenyl-3-yl)cyclopropanecarboxylic acid was isolated as a white solid. LC/MS calcd. for C28H26N4O4 (m/e) 482.0, obsd. 483.1 (M+H, ES+).

1. customThen, the solvent was removed under vacuum
2. filtrationThe resulting white solids were collected by filtration
3. washwashed with water and hexanes
4. customAfter air drying