Triethylamine → (4-{4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-4-yl]-phenyl}-cyclohexyl)-acetic acid ethyl ester

Participants

Reaction Conditions

Reaction Steps

To a light brown solution of 5-[4-(4-ethoxycarbonylmethyl-cyclohexyl)-phenyl]-3-methyl-3H-[1,2,3]triazole-4-carboxylic acid (37 mg, 0.099 mmol) in toluene (5 mL) was added triethylamine (20.2 mg, 27.8 μL, 0.199 mmol) at room temperature. To the resulting solution was added diphenylphosphoryl azide (30.2 mg, 23.6 μL, 0.11 mmol) followed by (R)-1-phenylethanol (13.4 mg, 13.2 μL, 0.11 mmol) at room temperature. The resulting solution was heated with oil bath to 81° C. and stirred for 1 h at which time TLC analysis indicated the absence of the starting material. Then, the reaction mixture was cooled to room temperature and the solvent was removed under vacuum. The crude residue was treated with dichloromethane (10 mL) and filtered. The filtrate was loaded onto an ISCO (40 g) column chromatography eluting with ethyl acetate in hexanes (0-100%). The desired fractions were combined and the solvent was removed under vacuum to obtain (4-{4-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-4-yl]-phenyl}-cyclohexyl)-acetic acid ethyl ester (17 mg, 35% yield) as a white solid. LC/MS calcd for C28H34N4O4 (m/e) 490, obsd. 491.3 [M+H, ES+].

Provenance & Evidence