Thiomorpholine → (6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridin-2-yl)-thiomorpholin-4-yl-methanone

HRID 631979Notes

Reaction equation

HRID 631979 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:3][CH2:2]1.[NH:20]1[CH2:25][CH2:24][S:23][CH2:22][CH2:21]1>>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([N:20]3[CH2:25][CH2:24][S:23][CH2:22][CH2:21]3)=[O:14])[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 67164ThiomorpholineHCID 710877336-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid

Product 1

HCID 71087918(6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridin-2-yl)-thiomorpholin-4-yl-methanone

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid (Example 14 a) and thiomorpholine (CAN 123-90-0) as starting materials, MS (LC/MS): 348.1 [M+H]+.

Sources & evidence

ORD record
ord-43ae36dfdd784b2d866712820318fc7f
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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