2-Methyloxan-4-amine → 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (2-methyl-tetrahydro-pyran-4-yl)-amide

HRID 632003Notes

Reaction equation

HRID 632003 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:17][CH:18]1[CH2:23][CH:22]([NH2:24])[CH2:21][CH2:20][O:19]1>>[CH3:17][CH:18]1[CH2:23][CH:22]([NH:24][C:14]([C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:13]=2)=[O:16])[CH2:21][CH2:20][O:19]1

Participants

3

Reactant 2

HCID 231239952-Methyloxan-4-amineHCID 247301356-(3-Chlorophenyl)picolinic acid

Product 1

HCID 711055496-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (2-methyl-tetrahydro-pyran-4-yl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and tetrahydro-2-methyl-2H-pyran-4-amine (CAN 89584-06-5) as starting materials, MS (EI): m/e=331.1 [M+H]+.

Sources & evidence

ORD record
ord-3ff4ec365276460aa8525a7aeb48a5ca
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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