Methyl 2-amino-2-methylpropanoate → 2-[(6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carbonyl)-amino]-2-methyl-propionic acid methyl ester
Reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:3][CH2:2]1.[CH3:20][O:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:25])[NH2:24]>>[CH3:20][O:21][C:22](=[O:27])[C:23]([NH:24][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([CH3:26])[CH3:25]Participants
3
Procedure
The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid (Example 14 a) and 2-methyl-alanine methyl ester as starting materials, MS (LC/MS): 362.2 [M+H]+.
Sources & evidence
- ORD record
- ord-40eb333e31494dec98e3b73c46bd9223
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321727B2
Reaction notes
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