2-Amino-2-ethylbutan-1-ol → 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-ethyl-1-hydroxymethyl-propyl)-amide

HRID 632007Notes

Reaction equation

HRID 632007 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[NH2:17][C:18]([CH2:23][CH3:24])([CH2:21][CH3:22])[CH2:19][OH:20]>>[CH2:21]([C:18]([NH:17][C:14]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([CH2:19][OH:20])[CH2:23][CH3:24])[CH3:22]

Participants

3

Reactant 2

HCID 143256072-Amino-2-ethylbutan-1-olHCID 247301356-(3-Chlorophenyl)picolinic acid

Product 1

HCID 710936436-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-ethyl-1-hydroxymethyl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and 2-amino-2-ethyl-1-butanol (CAN 19792-52-0) as starting materials, MS (LC/MS): 333.1 (M+H).

Sources & evidence

ORD record
ord-1c174aa8f4e940299b70fb46b40edc07
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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