Oxan-3-amine → 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (tetrahydro-pyran-3-yl)-amide

HRID 632008Notes

Reaction equation

HRID 632008 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[O:17]1[CH2:22][CH2:21][CH2:20][CH:19]([NH2:23])[CH2:18]1>>[O:17]1[CH2:22][CH2:21][CH2:20][CH:19]([NH:23][C:14]([C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:13]=2)=[O:16])[CH2:18]1

Participants

3

Reactant 2

HCID 5200320Oxan-3-amineHCID 247301356-(3-Chlorophenyl)picolinic acid

Product 1

HCID 711055546-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (tetrahydro-pyran-3-yl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and tetrahydro-2H-pyran-3-amine (CAN 120811-32-7) as starting materials, MS (LC/MS): 317.1 (M+H).

Sources & evidence

ORD record
ord-d339b964e5a141ca941e5cb3cbed3b47
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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