2-Oxa-6-azaspiro[3.3]heptane → (6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridin-2-yl)-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-methanone

HRID 632009Notes

Reaction equation

HRID 632009 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:3][CH2:2]1.[CH2:20]1[C:23]2([CH2:26][NH:25][CH2:24]2)[CH2:22][O:21]1>>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([N:25]3[CH2:26][C:23]4([CH2:20][O:21][CH2:22]4)[CH2:24]3)=[O:14])[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 231118872-Oxa-6-azaspiro[3.3]heptaneHCID 710877336-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid

Product 1

HCID 71087919(6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridin-2-yl)-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-methanone

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid (Example 14 a) and 2-oxa-6-azaspiro[3.3]heptane (CAN 174-78-7) as starting materials, MS (EI): m/e=344.3 [M+H]+.

Sources & evidence

ORD record
ord-8b76b2cc5ffe4147a784ef15312ed47d
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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