反应详情

温度

40 °C

Benzonitrile (40 mmol) was combined with L-cysteine (45 mmol) in 100 mL of 1:1 MeOH/pH 6.4 phosphate buffer solution. The reaction was stirred at 40° C. for 3 days. The precipitate was removed by filtration, and MeOH was removed using rotary evaporation. To the remaining solution was added 1M HCl to adjust to pH=2 under 0° C. The resulting precipitate was filtered to yield a white solid 2-phenyl-4,5-dihydrothiazole-4-carboxylic acid 42a, which was used directly to next step without purification.

1. customThe precipitate was removed by filtration, and MeOH
2. customwas removed
3. customevaporation
4. additionTo the remaining solution was added 1M HCl
5. customto adjust to pH=2 under 0° C
6. filtrationThe resulting precipitate was filtered