Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Cyclopentenyl-6-(cyclopropylmethoxy)-pyridine-2-carboxylic acid → 5-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Cyclopentenyl-6-(cyclopropylmethoxy)-pyridine-2-carboxylic acid | HCID 71087445 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 71087559 | 79% |
반응 단계
The mixture of 5-cyclopentenyl-6-(cyclopropylmethoxy)-pyridine-2-carboxylic acid (0.95 g, 4 mmol), Pd/C (10% w/w, 0.2 g) in 30 mL of ethanol in a hydrogen atmosphere was stirred for 4 h at room temperature. The mixture was filtered and the filtrate was evaporated to dryness to obtain the product (0.76 g, 79%) as white solid. The product was directly used for the next step; MS (LC/MS): 262.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09321727B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-3aa59af14f394c6bb42dfe90174fb6b1 |
| 출처 메모 | uspto-grants-2016_04 |