2-Amino-N,2-dimethylpropanamide → 5-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-methyl-1-methylcarbamoyl-ethyl)-amide

HRID 632033Notes

Reaction equation

HRID 632033 reaction equation
[CH:1]1([C:6]2[CH:7]=[CH:8][C:9]([C:17]([OH:19])=O)=[N:10][C:11]=2[O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:20][C:21]([CH3:27])([CH3:26])[C:22]([NH:24][CH3:25])=[O:23]>>[CH3:26][C:21]([NH:20][C:17]([C:9]1[CH:8]=[CH:7][C:6]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[C:11]([O:12][CH2:13][CH:14]2[CH2:15][CH2:16]2)[N:10]=1)=[O:19])([C:22](=[O:23])[NH:24][CH3:25])[CH3:27]

Participants

3

Reactant 2

HCID 187922142-Amino-N,2-dimethylpropanamideHCID 710875595-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 710935535-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-methyl-1-methylcarbamoyl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 39 b) and 2-amino-N,2-dimethyl-propanamide (CAN 106914-07-2) as starting materials, MS (LC/MS): 360.2 [M+H]+.

Sources & evidence

ORD record
ord-a7fef0fb2b1b4f3b8c75f6082e8c53a2
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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