1-Aminopiperidine → 6-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid piperidin-1-ylamide

HRID 632041Notes

Reaction equation

HRID 632041 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[CH3:15])[CH2:3][CH2:2]1.[N:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[N:16]1([NH:22][C:12]([C:10]2[CH:9]=[CH:8][C:7]([CH3:15])=[C:6]([O:5][CH2:4][CH:1]3[CH2:2][CH2:3]3)[N:11]=2)=[O:14])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 166581-AminopiperidineHCID 710875996-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid

Product 1

HCID 710877146-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid piperidin-1-ylamide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid (Example 36 d) and 1-piperidinamine (CAN 2213-43-6) as starting materials, MS (EI): m/e 290.2 [M+H]+.

Sources & evidence

ORD record
ord-61991f3b58c64f7d89c56023c3982804
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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