反应详情

温度

120 °C

6-Bromo-5-methyl-pyridine-2-carbonitrile (1.0 g, 5.0 mmol) was added to a solution of sodium hydroxide (0.3 g, 7 mmol) in water (20 mL), the mixture was stirred at 120° C. overnight. Subsequently, the mixture was adjusted to pH=3 and extracted with ethyl acetate (2×15 mL). The organic extracts were washed with brine, dried over anhydrous sodium sulfate and concentrated to give the product (0.7 g, 63.8%); MS (EI): m/e 216.0 [M+H]+.

1. extractionextracted with ethyl acetate (2×15 mL)
2. washThe organic extracts were washed with brine
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated