1-Aminopiperidine → 6-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid piperidin-1-yl-amide

HRID 632051Notes

Reaction equation

HRID 632051 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[CH3:17])[CH:5]=[CH:6][CH:7]=1.[N:18]1([NH2:24])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[N:18]1([NH:24][C:14]([C:12]2[CH:11]=[CH:10][C:9]([CH3:17])=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:13]=2)=[O:16])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 166581-AminopiperidineHCID 710878026-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid

Product 1

HCID 710874586-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid piperidin-1-yl-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid (Example 49 e) and 1-piperidinamine (CAN 2213-43-6) as starting materials, MS (D): 330.1 [M+H]+.

Sources & evidence

ORD record
ord-75efa799eb7f4eb9b68fdfcffc6c10dd
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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