6-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid → 6-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid [(S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

HRID 632059Notes

Reaction equation

HRID 632059 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[CH3:15])[CH2:3][CH2:2]1.[CH:16]1([CH2:19][C@H:20]([NH2:27])[C:21]2[N:25]=[C:24]([CH3:26])[O:23][N:22]=2)[CH2:18][CH2:17]1>>[CH:16]1([CH2:19][C@H:20]([NH:27][C:12]([C:10]2[CH:9]=[CH:8][C:7]([CH3:15])=[C:6]([O:5][CH2:4][CH:1]3[CH2:2][CH2:3]3)[N:11]=2)=[O:14])[C:21]2[N:25]=[C:24]([CH3:26])[O:23][N:22]=2)[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 710875996-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acidHCID 86674748(S)-2-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine

Product 1

HCID 711055686-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid [(S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid (Example 36 d) and (S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (Example 38 e) as starting materials, MS (EI): m/e 357.2 [M+H]+.

Sources & evidence

ORD record
ord-5e17d460674b4734b12ab617563ff95e
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

Loading…