2-(1,3-Thiazol-2-yl)propan-2-amine → 6-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide

HRID 632067ノート

反応式

HRID 632067 の反応式
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[CH3:15])[CH2:3][CH2:2]1.[CH3:16][C:17]([CH3:24])([C:19]1[S:20][CH:21]=[CH:22][N:23]=1)[NH2:18]>>[CH3:16][C:17]([NH:18][C:12]([C:10]1[CH:9]=[CH:8][C:7]([CH3:15])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([C:19]1[S:20][CH:21]=[CH:22][N:23]=1)[CH3:24]

参加物

3

反応物 2

HCID 282862032-(1,3-Thiazol-2-yl)propan-2-amineHCID 710875996-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid

生成物 1

HCID 711055726-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide

実験手順

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid (Example 36 d) and α,α-dimethyl-2-thiazolemethanamine (CAN 1082393-38-1) as starting materials, MS (EI): m/e=332.2 [M+H]+.

出典と根拠

ORDレコード
ord-9cbbfe4e3ccd451ba6cf6447782a00c6
出典データセット
uspto-grants-2016_04
特許番号
US09321727B2

反応ノート

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